Intra-medial prefrontal cortex injections of scopolamine increase instrumental responses for cocaine: an intravenous self-administration study in rats
S Ikemoto, NE Goeders - Brain research bulletin, 2000 - Elsevier
The present experiments examined the effects of muscarinic cholinergic receptor blockade
in the nucleus accumbens (NAC) and medial prefrontal cortex (MPC) on intravenous
cocaine self-administration. Adult male Sprague–Dawley rats were implanted with chronic
indwelling jugular catheters and guide cannulae stereotaxically aimed at the NAC or MPC.
The rats were then given the opportunity to intravenously self-administer cocaine (0.8
mg/kg/infusion) during daily 2-h sessions. Intra-NAC microinjections of methyl-scopolamine …
in the nucleus accumbens (NAC) and medial prefrontal cortex (MPC) on intravenous
cocaine self-administration. Adult male Sprague–Dawley rats were implanted with chronic
indwelling jugular catheters and guide cannulae stereotaxically aimed at the NAC or MPC.
The rats were then given the opportunity to intravenously self-administer cocaine (0.8
mg/kg/infusion) during daily 2-h sessions. Intra-NAC microinjections of methyl-scopolamine …
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